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KMID : 0378019820250050041
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New Medical Journal
1982 Volume.25 No. 5 p.41 ~ p.44
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Clinical Observation of Gout
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Abstract
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Gout is familiar inborn error (6^-80%) of purine metabolism in which is characterized elevation of serum uric acid and deposited to various mesenchymal tissues and surround by foreign body and inflammatory reaction. Clinically it is characterized by acute attack of arthritis, interval of freedom from pain, and in late stages by crippling deforming arthritis, nephritis, urinary calculi and cardiovascular lesion.
Twenty six patients with gout managed at the department. of orthopedic surgery, National police Hospital, from Feb., 1972 to Aug. 1981, Were reviewed and following results were obtained.
? Most of cases were between 30yrs and 55yrs old and all the cases were male.
(2 The most common season of occurrence of acute attack was spring and the least common season was summer.
´) The recurring attacks were more frequent than the first attack.
) The precipitating factors could be found usually including family history, dietary indiscretion, cold exposure and stress condition.
? The everage serum uric acid level during acute attacks showed 10.65mg% and the all cases exceps 5 cases noted in creased ESR mith everage 31.5mm/hr. The lenkocytosis were noted in 8 cases.
60 The first involved joints was the m-p joint of bigtoe in 20 cases and the knee joint in 4 cases
? The radiological multiple punched out bone lesion were found in 11 cases.
? One tablet (0.65mg) of colchicine was given every hour until the diarrhea appeared
or the pain was subsided in 26 cases. Among them, when 10 tablets of colchicin were
given, the diarrhea appeared. and the pain subsided in 16 cases. So we recommended
7-8 tablets for relief of pain without G.I_ discomfort in management of gout.
? The forewarning symptoms were found in case of 9 patients such as mood change,
constipation, diuresis.
? We also adviced the general measure to avoid high purine diet such as liver, kidney, brain, sweetbread, anchovy, sardine, beer and also adviced took plenty of fluid during daytime and reduced protein and fat intake.
Q The case of gouty arthritis may be found more and more in our country because the stress condition and meat intake might be increased such as Europe & America.
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KEYWORD
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